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Article

Role of excretion in manganese homeostasis and neurotoxicity: a historical perspective.

American journal of physiology. Gastrointestinal and liver physiology - 1 Jan 2022

Gurol Kerem C, Aschner Michael, Smith Donald R, Mukhopadhyay Somshuvra

Abstract excerpt

The essential metal manganese (Mn) induces incurable neurotoxicity at elevated levels that manifests as parkinsonism in adults and fine motor and executive function deficits in children. Studies on Mn neurotoxicity have largely focused on the role and mechanisms of disease induced by elevated Mn exposure from occupational or environmental sources. In contrast, the critical role of excretion in regulating Mn...

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Identifiers

PMID: 34786983
DOI: 10.1152/ajpgi.00299.2021
PMCID: PMC8714252

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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