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Article

SLC30A10 is a cell surface-localized manganese efflux transporter, and parkinsonism-causing mutations block its intracellular trafficking and efflux activity.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Oct 2014

Leyva-Illades Dinorah, Chen Pan, Zogzas Charles E, Hutchens Steven, Mercado Jonathan M, Swaim Caleb D, Morrisett Richard A, Bowman Aaron B, Aschner Michael, Mukhopadhyay Somshuvra

Abstract excerpt

Manganese (Mn) is an essential metal, but elevated cellular levels are toxic and may lead to the development of an irreversible parkinsonian-like syndrome that has no treatment. Mn-induced parkinsonism generally occurs as a result of exposure to elevated Mn levels in occupational or environmental settings. Additionally, patients with compromised liver function attributable to diseases, such as cirrhosis, fail to...

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PMID: 25319704
DOI: 10.1523/JNEUROSCI.2329-14.2014
PMCID: PMC4198546

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