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Article

Up-regulation of the manganese transporter SLC30A10 by hypoxia-inducible factors defines a homeostatic response to manganese toxicity.

Proceedings of the National Academy of Sciences of the United States of America - 31 Aug 2021

Liu Chunyi, Jursa Thomas, Aschner Michael, Smith Donald R, Mukhopadhyay Somshuvra

Abstract excerpt

Manganese (Mn) is an essential metal that induces incurable parkinsonism at elevated levels. However, unlike other essential metals, mechanisms that regulate mammalian Mn homeostasis are poorly understood, which has limited therapeutic development. Here, we discovered that the exposure of mice to a translationally relevant oral Mn regimen up-regulated expression of SLC30A10, a critical Mn efflux transporter, in...

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Identifiers

PMID: 34446561
DOI: 10.1073/pnas.2107673118
PMCID: PMC8536340

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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