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Article

Manganese homeostasis: from rare single-gene disorders to complex phenotypes and diseases.

The Journal of clinical investigation - 2 Dec 2019

Katz Nathan, Rader Daniel J

Abstract excerpt

Manganese (Mn) participates in a variety of distinct physiological processes, including acting as a cofactor for several enzymes and metalloenzymes, in addition to playing a role in immune function, endocrine function, hematopoiesis, and oxidative stress regulation. Mn homeostasis is tightly regulated via intestinal absorption and hepatobiliary and intestinal excretion. In this issue of the JCI, Mercadante and...

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Identifiers

PMID: 31682237
DOI: 10.1172/JCI133120
PMCID: PMC6877306

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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