Article
Apolipoprotein E genotypes and plasma levels in mild cognitive impairment conversion to Alzheimer's disease: A follow-up study.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Dec 2016
Scarabino Daniela, Broggio Elisabetta, Gambina Giuseppe, Maida Carlotta, Gaudio Maria Rosa, Corbo Rosa Maria
Abstract excerpt
Mild cognitive impairment (MCI) is the transition stage between the normal aging process and dementia itself. The most common clinical phenotype is amnestic MCI (aMCI) [subtypes: single domain (sMCI) and multiple domains (mMCI)], which is considered prodromal to Alzheimer's disease (AD). The APOE (apolipoprotein E) e4 allele is the most important genetic risk factor for AD, but its association with MCI onset and...
Topics
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Apolipoproteins E
- Cognition Disorders
- Cognitive Dysfunction
- Dementia
- Disease Progression
- Female