Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Is the apolipoprotein e genotype a biomarker for mild cognitive impairment? Findings from a nationally representative study.

Neuropsychology - 1 Nov 2011

Brainerd Charles J, Reyna Valerie F, Petersen Ronald C, Smith Glenn E, Taub Emily S

Abstract excerpt

OBJECTIVE: Although the ε4 allele of the apolipoprotein E (APOE) genotype is a known risk factor for Alzheimer's dementia (AD), prior findings on whether it is also a risk factor for mild cognitive impairment (MCI) have been inconsistent. We tested two contrasting explanations: (a) an ε4-AD specificity hypothesis, and (b) a measurement insensitivity hypothesis. METHOD: The frequency of the ε4 allele was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over
Share to Aging

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Genetic Markers

Share to Genetic Testing

Share to Genotype

Share to Reference Values

Source

Identifiers

PMID: 21728427
DOI: 10.1037/a0024483

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Is the apolipoprotein e genotype a biomarker for mild cognitive impairment? Findings from a nationally representative study.PMID 21728427Read ↗

The apolipoprotein E genotype predicts longitudinal transitions to mild cognitive impairment but not to Alzheimer's dementia: findings from a nationally representative study.Semantic proximity Read ↗

APOE ε2ε4 genotype, incident AD and MCI, cognitive decline, and AD pathology in older adults.Semantic proximity Read ↗

The Effect of the APOE ε2ε4 Genotype on the Development of Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) in Non-Latino Whites.Semantic proximity Read ↗

Predictive value of APOE-ε4 allele for progression from MCI to AD-type dementia: a meta-analysis.Semantic proximity Read ↗

Lack of reliable evidence for a distinctive ε4-related cognitive phenotype that is independent from clinical diagnostic status: findings from the Australian Imaging, Biomarkers and Lifestyle Study.Semantic proximity Read ↗

Effect of apolipoprotein E ε4 allele on the progression of cognitive decline in the early stage of Alzheimer's diseaseSemantic proximity Read ↗

Accelerated progression from mild cognitive impairment to dementia among APOE ε4ε4 carriers.Semantic proximity Read ↗

Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease.Semantic proximity Read ↗

Predictive utility of apolipoprotein E genotype for Alzheimer disease in outpatients with mild cognitive impairment.Semantic proximity Read ↗

The Link between APOE4 Presence and Neuropsychological Test Performance among Mexican Americans and Non-Hispanic Whites of the Multiethnic Health & Aging Brain Study – Health Disparities CohortSemantic proximity Read ↗

The influence of APOE status on cognitive declineSemantic proximity Read ↗

Apolipoprotein E genotypes and plasma levels in mild cognitive impairment conversion to Alzheimer's disease: A follow-up study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.