Article
Is the apolipoprotein e genotype a biomarker for mild cognitive impairment? Findings from a nationally representative study.
Neuropsychology - 1 Nov 2011
Brainerd Charles J, Reyna Valerie F, Petersen Ronald C, Smith Glenn E, Taub Emily S
Abstract excerpt
OBJECTIVE: Although the ε4 allele of the apolipoprotein E (APOE) genotype is a known risk factor for Alzheimer's dementia (AD), prior findings on whether it is also a risk factor for mild cognitive impairment (MCI) have been inconsistent. We tested two contrasting explanations: (a) an ε4-AD speci...
Topics
- Aged
- Aged, 80 and over
- Aging
- Analysis of Variance
- Apolipoprotein E4
- Cognitive Dysfunction
- Dementia
- Female
- Gene Frequency
- Genetic Markers
- Genetic Testing
- Genotype
- Humans
- Male
- National Institute on Aging (U.S.)
- Neuropsychological Tests
- Reference Values
- Reproducibility of Results