Article

Direct reprogramming of adult hepatocytes to generate LGR5+ endodermal progenitor

2020-05-31

Abstract excerpt

We successfully converted hepatocytes isolated from adult mice into expandable and stable leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5)-positive endodermal progenitor cells (EndoPCs). This was accomplished in vitro through transient exposure to four transcriptional factors (OCT3/4, SOX2, KLF4, and cMYC) and STAT3 activators. EndoPCs were generated by a process that involved an epithelial-mese...

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Literature Corpus work: eae2c10d-2ae9-5c15-8304-e4f5c4b8b845
DOI: 10.1101/2020.05.29.123273

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