Back to search

Article

Genome-Scale CRISPR Screening reveals novel factors regulating Wnt-dependent regeneration of mouse gastric organoids

2020-07-17

Abstract excerpt

<h4>ABSTRACT</h4> An ability to safely harness the powerful regenerative potential of adult stem cells for clinical applications is critically dependent on a comprehensive understanding of the underlying mechanisms regulating their activity. Epithelial organoid cultures accurately recapitulate many features of in vivo stem cell-driven epithelial regeneration, providing an excellent ex vivo platform for interrog...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
1df8d0be-99dc-5d51-995b-4b1080058e9d
DOI
10.1101/2020.07.17.208496
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Genome-Scale CRISPR Screening reveals novel factors regulating Wnt-dependent regeneration of mouse gastric organoidsDOI 10.1101/2020.07.17.208496
The critical role of BMP signaling in gastric epithelial cell differentiation revealed by organoidsSemantic proximity
Mini-Gut Organoids: Reconstitution of the Stem Cell NicheSemantic proximity
Strategies for genetic manipulation of adult stem cell-derived organoidsSemantic proximity
Establishment of intestinal organoid cultures modeling injury-associated epithelial regenerationSemantic proximity
Identification, Isolation, and Characterization of Human LGR5-positive Colon Adenoma CellsSemantic proximity
Identification, isolation and characterization of human LGR5-positive colon adenoma cellsSemantic proximity
The Origins of Gastric Cancer From Gastric Stem Cells: Lessons From Mouse ModelsSemantic proximity
Lgr5-expressing chief cells drive epithelial regeneration and cancer in the oxyntic stomach.Semantic proximity
Gastric Stem Cells: Physiological and Pathological PerspectivesSemantic proximity
Spatial organisation and homeostasis of epithelial lineages at the gastroesophageal junction is regulated by the divergent Wnt mucosal microenvironmentSemantic proximity
Invasive mouse gastric adenocarcinomas arising from Lgr5+ stem cells are dependent on crosstalk between the Hedgehog/GLI2 and mTOR pathwaysSemantic proximity
Single Cell Analysis Reveals Multi-faceted miR-375 Regulation of the Intestinal CryptSemantic proximity
Select a neighboring publication to make it the new centre.