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Lgr5 + pericentral hepatocytes are self-maintained in normal liver regeneration and susceptible to hepatocarcinogenesis

5 Sept 2019

Abstract excerpt

Significance Liver has a remarkable regenerative capacity following injuries. However, the cellular dynamics of how hepatocytes are replenished during homeostasis and upon liver injuries remains largely unclear. By using genetic lineage tracing strategies on rare Lgr5 + hepatocytes surrounding the central veins of the liver lobule, this study shows that Lgr5 + hepatocytes are self-maintained during normal...

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PMID: 31488716
DOI: 10.1073/pnas.1908099116

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