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Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications

6 Jun 2013

Abstract excerpt

Recent examples have highlighted how stem cells have the capability to initiate morphogenesis in vitro; that is, to generate complex structures in culture that closely parallel their in vivo counterparts. Lgr5, the receptor for the Wnt-agonistic R-spondins, marks stem cells in multiple adult organs of mice and humans. In R-spondin-based three-dimensional cultures, these Lgr5 stem cells can grow into...

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PMID: 23744940
DOI: 10.1126/science.1234852

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