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Article

Identification of a Novel RUNX1::STX2 Fusion in Mixed-Phenotype Acute Leukemia (MPAL) With BCR::ABL1.

Molecular carcinogenesis - 1 Feb 2025

Long Yuan, Xu Qi, Li Jing, Liu Bei-Cai, Cheng Peng, Luo Jun, Zhao Shengbin, Chen Ping, Liu Zhen-Fang

Abstract excerpt

Mixed phenotype acute leukemia (MPAL) is a rare type of acute leukemia (AL), MPAL with BCR::ABL1 fusion is the main subtype of MPAL, mainly affecting adult males. It is an acute leukemia with unique clinical and biological characteristics that involve both the myeloid and lymphatic systems. Gene fusion plays a crucial role in the pathogenesis, diagnosis, prognosis assessment, and treatment of leukemia. We present...

Read the complete abstract on PubMed

Topics

Humans
Core Binding Factor Alpha 2 Subunit
Male
Oncogene Proteins, Fusion
Fusion Proteins, bcr-abl
Leukemia, Biphenotypic, Acute

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Phenotype

Adult

Source

Identifiers

PMID: 39601532
DOI: 10.1002/mc.23850

Genes

RUNX1
STX2
ABL1
BCR

Provenance

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