Article
Response of V79 cells to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) treatment: inhibition of poly(ADP-ribose) and topoisomerase activity.
Mutation research - 1 Jul 1991
Roy M, Ghosh R, Dey S K, Bhattacharjee S B
Abstract excerpt
MNNG-induced killing of V79 cells has been found to be enhanced on inhibition of topoisomerase II activity by nalidixic acid and poly(ADP-ribose) polymerase synthesis by benzamide. Using these 2 inhibitors in conjunction after MNNG treatment, some overlap in the functions of these 2 enzymes was observed. Nalidixic acid and benzamide were found to suppress the yields of mutations and SCEs induced by MNNG....
Topics
- Adenosine Diphosphate Ribose
- Animals
- Benzamides
- Cell Line
- Cell Survival
- Cricetinae
- Cricetulus
- Methylnitronitrosoguanidine
- Mutagens
- Mutation
- Nalidixic Acid