Article
DNA methylation alterations exhibit intraindividual stability and interindividual heterogeneity in prostate cancer metastases.
Science translational medicine - 23 Jan 2013
Aryee Martin J, Liu Wennuan, Engelmann Julia C, Nuhn Philipp, Gurel Meltem, Haffner Michael C, Esopi David, Irizarry Rafael A, Getzenberg Robert H, Nelson William G, Luo Jun, Xu Jianfeng, Isaacs William B, Bova G Steven, Yegnasubramanian Srinivasan
Abstract excerpt
Human cancers almost ubiquitously harbor epigenetic alterations. Although such alterations in epigenetic marks, including DNA methylation, are potentially heritable, they can also be dynamically altered. Given this potential for plasticity, the degree to which epigenetic changes can be subject to selection and act as drivers of neoplasia has been questioned. We carried out genome-scale analyses of DNA methylation...
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