Intraindividual epigenetic heterogeneity underlying phenotypic subtypes of advanced prostate cancer

Abstract excerpt

Castration-resistant prostate cancer is a heterogeneous disease with variable phenotypes commonly observed in later stages of the disease. These include cases that retain expression of luminal markers and those that lose hormone dependence and acquire neuroendocrine features. While there are distinct transcriptomic and epigenomic differences between castration-resistant adenocarcinoma and neuroendocrine prostate...

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• Cancer-related molecular mechanisms research
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