Article
The DNA methylation landscape of advanced prostate cancer.
Nature genetics - 1 Aug 2020
Zhao Shuang G, Chen William S, Li Haolong, Foye Adam, Zhang Meng, Sjöström Martin, Aggarwal Rahul, Playdle Denise, Liao Arnold, Alumkal Joshi J, Das Rajdeep, Chou Jonathan, Hua Junjie T, Barnard Travis J, Bailey Adina M, Chow Eric D, Perry Marc D, Dang Ha X, Yang Rendong, Moussavi-Baygi Ruhollah, Zhang Li, Alshalalfa Mohammed, Laura Chang S, Houlahan Kathleen E, Shiah Yu-Jia, Beer Tomasz M, Thomas George, Chi Kim N, Gleave Martin, Zoubeidi Amina, Reiter Robert E, Rettig Matthew B, Witte Owen, Yvonne Kim M, Fong Lawrence, Spratt Daniel E, Morgan Todd M, Bose Rohit, Huang Franklin W, Li Hui, Chesner Lisa, Shenoy Tanushree, Goodarzi Hani, Asangani Irfan A, Sandhu Shahneen, Lang Joshua M, Mahajan Nupam P, Lara Primo N, Evans Christopher P, Febbo Phillip, Batzoglou Serafim, Knudsen Karen E, He Housheng H, Huang Jiaoti, Zwart Wilbert, Costello Joseph F, Luo Jianhua, Tomlins Scott A, Wyatt Alexander W, Dehm Scott M, Ashworth Alan, Gilbert Luke A, Boutros Paul C, Farh Kyle, Chinnaiyan Arul M, Maher Christopher A, Small Eric J, Quigley David A, Feng Felix Y
Abstract excerpt
Although DNA methylation is a key regulator of gene expression, the comprehensive methylation landscape of metastatic cancer has never been defined. Through whole-genome bisulfite sequencing paired with deep whole-genome and transcriptome sequencing of 100 castration-resistant prostate metastases, we discovered alterations affecting driver genes that were detectable only with integrated whole-genome approaches....
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