Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The telomere/telomerase binding factor <scp>PinX1</scp> is a new target to improve the radiotherapy effect of oesophageal squamous cell carcinomas

23 Jan 2013

Abstract excerpt

Chemoradiotherapy (CRT) is a standard treatment for oesophageal squamous cell carcinoma (ESCC) in its advanced stages. The telomerase/telomere interacting protein PinX1 contributes to telomere maintenance, tumourigenicity, and influences the DNA damage agent-induced apoptotic response in telomerase-positive cancer cells. However, the clinical and biological significance of PinX1 in human ESCCs remains unclear. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Radiation Therapy and Dosimetry
Share to Renal and related cancers
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23341363
DOI: 10.1002/path.4163

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The telomere/telomerase binding factor <scp>PinX1</scp> is a new target to improve the radiotherapy effect of oesophageal squamous cell carcinomasPMID 23341363Read ↗

The depletion of PinX1 involved in the tumorigenesis of non-small cell lung cancer promotes cell proliferation via p15/cyclin D1 pathwaySemantic proximity Read ↗

FOXK1 regulates malignant progression and radiosensitivity through direct transcriptional activation of CDC25A and CDK4 in esophageal squamous cell carcinomaSemantic proximity Read ↗

Silencing PinX1 Compromises Telomere Length Maintenance As Well As Tumorigenicity in Telomerase-Positive Human Cancer CellsSemantic proximity Read ↗

PinX1 the tail on the chromosomeSemantic proximity Read ↗

Silencing of the hPOT1 gene by RNA inference promotes apoptosis and inhibits proliferation and aggressive phenotype of gastric cancer cells, likely through up-regulating PinX1 expression.Semantic proximity Read ↗

APE1 promotes radiation resistance against radiation-induced pyroptosis by inhibiting the STING pathway in lung adenocarcinomaSemantic proximity Read ↗

YAP1-TEAD4-DKK1 is an effective target for inhibiting radiation resistance in esophageal squamous carcinoma and activation of the pathway may be related to poor prognosis of patientsSemantic proximity Read ↗

YTHDF1 promotes radio-resistance and regulates the repair of DNA double-strand breaks in ESCCSemantic proximity Read ↗

PinX1, a Telomere Repeat-binding Factor 1 (TRF1)-interacting Protein, Maintains Telomere Integrity by Modulating TRF1 Homeostasis, the Process in Which Human Telomerase Reverse Transcriptase (hTERT) Plays Dual RolesSemantic proximity Read ↗

The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in miceSemantic proximity Read ↗

Silencing of XRCC4 increases radiosensitivity of triple-negative breast cancer cellsSemantic proximity Read ↗

PITX1 protein interacts with ZCCHC10 to regulate <i>hTERT</i> mRNA transcriptionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.