Article

PITX1 protein interacts with ZCCHC10 to regulate <i>hTERT</i> mRNA transcription

2019-05-16

Abstract excerpt

Telomerase is a ribonucleoprotein ribonucleic enzyme that is essential for cellular immortalization via elongation of telomere repeat sequences at the end of chromosomes. Human telomerase reverse transcriptase ( hTERT ), the catalytic subunit of telomerase holoenzyme, is a key regulator of telomerase activity. Telomerase activity, which has been detected in the majority of cancer cells, is accompanied by hTERT...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a005e145-4687-5bd8-bc75-12d40760a451
DOI: 10.1101/640508

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PITX1 protein interacts with ZCCHC10 to regulate <i>hTERT</i> mRNA transcriptionDOI 10.1101/640508Read

Identification of <i>PITX1</i> as a <i>TERT</i> Suppressor Gene Located on Human Chromosome 5Semantic proximity Read

Silencing PinX1 Compromises Telomere Length Maintenance As Well As Tumorigenicity in Telomerase-Positive Human Cancer CellsSemantic proximity Read

Characterization of Interactions between PinX1 and Human Telomerase Subunits hTERT and hTRSemantic proximity Read

The depletion of PinX1 involved in the tumorigenesis of non-small cell lung cancer promotes cell proliferation via p15/cyclin D1 pathwaySemantic proximity Read

PinX1 the tail on the chromosomeSemantic proximity Read

PATZ1 acts as a tumor suppressor in thyroid cancer via targeting p53-dependent genes involved in EMT and cell migrationSemantic proximity Read

High PITX1 expression in lung adenocarcinoma patients is associated with DNA methylation and poor prognosisSemantic proximity Read

The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in miceSemantic proximity Read

Positive feedback loop of c-myc/XTP6/NDH2/NF-κB to promote malignant progression in glioblastomaSemantic proximity Read

The telomere/telomerase binding factor <scp>PinX1</scp> is a new target to improve the radiotherapy effect of oesophageal squamous cell carcinomasSemantic proximity Read

METTL1-driven epitranscriptomic enhancement of TXNDC12 boosts c-Myc stability through USP5 in HNSCCSemantic proximity Read

Characterization of the Translationally Controlled Tumor Protein (TCTP) Interactome Reveals Novel Binding Partners in Human Cancer CellsSemantic proximity Read