Article
Silencing of the hPOT1 gene by RNA inference promotes apoptosis and inhibits proliferation and aggressive phenotype of gastric cancer cells, likely through up-regulating PinX1 expression.
Journal of clinical pathology - 1 Dec 2011
Wan Shun-Mei, Tie Jun, Zhang Ya-Fei, Guo Jun, Yang Liu-Qin, Wang Jun, Xia Shi-Hai, Yang Shi-Ming, Wang Rong-Quan, Fang Dian-Chun
Abstract excerpt
BACKGROUND: The human protection of telomeres 1 (hPOT1) protein, a single-strand telomeric DNA binding protein, plays an important role in telomere protection and telomere length regulation. However, its effect on invasion of gastric cancer remains unclear. AIMS: To explore the role of hPOT1 in t...
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