Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The depletion of PinX1 involved in the tumorigenesis of non-small cell lung cancer promotes cell proliferation via p15/cyclin D1 pathway

4 Apr 2017

Abstract excerpt

BACKGROUND: The telomerase/telomere interacting protein PinX1 has been suggested as a tumor suppressor. However, the clinical and biological significance of PinX1 in human non-small cell lung cancer (NSCLC) is unclear. METHODS: PinX1 gene/expression pattern and its association with NSCLC patient survival were analyzed in cBioportal Web resource and two cohorts of NSCLC samples. A series of in vivo and in vitro...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to Microtubule and mitosis dynamics
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28372542
DOI: 10.1186/s12943-017-0637-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The depletion of PinX1 involved in the tumorigenesis of non-small cell lung cancer promotes cell proliferation via p15/cyclin D1 pathwayPMID 28372542Read ↗

Silencing PinX1 Compromises Telomere Length Maintenance As Well As Tumorigenicity in Telomerase-Positive Human Cancer CellsSemantic proximity Read ↗

The telomere/telomerase binding factor <scp>PinX1</scp> is a new target to improve the radiotherapy effect of oesophageal squamous cell carcinomasSemantic proximity Read ↗

MEOX1 suppresses the progression of lung cancer cells by inhibiting the cell‐cycle checkpoint gene CCNB1Semantic proximity Read ↗

The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in miceSemantic proximity Read ↗

CNOT4 suppresses nonsmall cell lung cancer progression by promoting the degradation of PAF1Semantic proximity Read ↗

PITX1 protein interacts with ZCCHC10 to regulate <i>hTERT</i> mRNA transcriptionSemantic proximity Read ↗

An SETD1A/Wnt/β-catenin feedback loop promotes NSCLC developmentSemantic proximity Read ↗

High PITX1 expression in lung adenocarcinoma patients is associated with DNA methylation and poor prognosisSemantic proximity Read ↗

ALOX15, a new potential functional target of lung adenocarcinomaSemantic proximity Read ↗

Transcription factor E2F1 promotes non-small cell lung cancer progression by activating the PI3K/AKT pathway through MCM4Semantic proximity Read ↗

KIN17 modulates cell proliferation and migration through the WNT/β-catenin signal pathways in non-small cell lung cancerSemantic proximity Read ↗

Impact of CD151 overexpression on prognosis and therapy in non-small cell lung cancer patients lacking EGFR mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.