PinX1 the tail on the chromosome

Abstract excerpt

The PinX1 protein inhibits telomerase, an enzyme that lengthens telomeres - the structures that protect the ends of chromosomes. Loss of PinX1 leads to increased telomere length along with defects in chromosome dynamics. In this issue of the JCI, Zhou et al. present novel evidence from human tumors and mouse models indicating that PinX1 is a clinically significant tumor suppressor. Importantly, the...

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• Share to Advanced biosensing and bioanalysis techniques
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• Share to Telomeres, Telomerase, and Senescence