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Article

Variations in ncRNA gene LOC284889 and MIF-794CATT repeats are associated with malaria susceptibility in Indian populations.

Malaria journal - 25 Sept 2013

Jha Aditya N, Sundaravadivel Pandarisamy, Pati Sudhanshu S, Patra Pradeep K, Thangaraj Kumarasamy

Abstract excerpt

BACKGROUND: There are increasing evidences on the role of non-coding RNA (ncRNA) as key regulator of cellular homeostasis. LOC284889 is an uncharacterized ncRNA gene on reverse strand to MIF mapped to 22q11.23. MIF, a lymphokine, regulates innate immune response by up-regulating the expression of TLR4, suppressing the p53 activity and has been shown to be involved in malaria pathogenesis. METHODS: In this study,...

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Identifiers

PMID: 24066864
DOI: 10.1186/1475-2875-12-345
PMCID: PMC3849407

Genes

MIF
TLR4

Provenance

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