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Article

Evidence that interferon-gamma plays a protective role during cerebral malaria.

The Journal of infectious diseases - 1 Sept 2005

Cabantous Sandrine, Poudiougou Belco, Traore Abdoulaye, Keita Marouf, Cisse Mamadou Balla, Doumbo Ogobara, Dessein Alain J, Marquet Sandrine

Abstract excerpt

BACKGROUND: The pathogenic mechanisms of cerebral malaria (CM) are unclear but are thought to involve cytokine-mediated inflammation enhanced by parasite sequestration in the brain microcirculation. The role that interferon (IFN)-gamma could play that would enhance inflammation but also reduce pa...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16088835
DOI: 10.1086/432484

Genes

IFNG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16088835-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence that interferon-gamma plays a protective role during cerebral malaria.PMID 16088835Read ↗

A rare non-synonymous c.102C>G SNP in the IFNB1 gene might be a risk factor for cerebral malaria in Indian populations.Semantic proximity Read ↗

TLR9 polymorphisms are associated with altered IFN-gamma levels in children with cerebral malaria.Semantic proximity Read ↗

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IFN-λ4 is associated with increased risk and earlier occurrence of several common infections in African children.Semantic proximity Read ↗

IFN-λ4 is associated with increased risk and earlier occurrence of gastrointestinal, respiratory and malarial infections in Malian childrenSemantic proximity Read ↗

Interferon-alpha receptor-1 (IFNAR1) variants are associated with protection against cerebral malaria in the Gambia.Semantic proximity Read ↗

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Genetic evidence for the aggravation of Plasmodium falciparum malaria by interleukin 4.Semantic proximity Read ↗

CXCL10 gene promoter polymorphism -1447A>G correlates with plasma CXCL10 levels and is associated with male susceptibility to cerebral malaria.Semantic proximity Read ↗

Association of Early Interferon‐γ Production with Immunity to Clinical Malaria: A Longitudinal Study among Papua New Guinean ChildrenSemantic proximity Read ↗

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