Article
Accumulation of inactive p53 protein in oral squamous cell carcinoma: stabilization by protein interaction.
European journal of oral sciences - 1 Feb 2013
Francis Geo, Dileep Kumar U, Nalinakumari K R, Jayasree K, Kannan S
Abstract excerpt
Our previous study showed that p53 protein is accumulated in >60% of cases of oral squamous cell carcinoma (OSCC) and its overexpression is related to poor prognosis. However, the mechanism behind this is still elusive. The present study attempts to dissect p53 alterations at various levels from gene to function in tumor biopsies to understand whether molecular alterations have any relationship with the...
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