Article
New insights into p53 protein stabilisation in oral squamous cell carcinoma.
Oral oncology - 1 Jan 1999
Partridge M, Kiguwa S, Emilion G, Pateromichelakis S, A'Hern R, Langdon J D
Abstract excerpt
p53 is a transcription factor which regulates cell proliferation and apoptosis to prevent division of potentially malignant cells. In many tumours mutation of the p53 gene leads to stabilisation of this protein which can be detected by immunohistochemistry (IHC). However, there are many reports describing detection of p53 by IHC in the absence of gene mutation, and in these cases other factors stabilise p53. To...
Topics
- Adult
- Aged
- Blotting, Northern
- Carcinoma, Squamous Cell
- Female
- Genes, p53
- Humans
- Immunohistochemistry
- Loss of Heterozygosity
- Male
- Microsatellite Repeats
- Middle Aged
- Mouth Neoplasms
- Mutation
- Nuclear Proteins
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Proto-Oncogene Proteins