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Article

p53 protein accumulation in European hepatocellular carcinoma is not always dependent on p53 gene mutation.

Gastroenterology - 1 Apr 1995

Bourdon J C, D'Errico A, Paterlini P, Grigioni W, May E, Debuire B

Abstract excerpt

BACKGROUND/AIMS: Immunohistochemical reactivity for p53 protein is common in various human malignancies and often related to p53 gene mutation. However, in some tumor types, accumulation of wild-type p53 has been shown. Previously, we analyzed 96 European hepatocellular carcinomas using immunohistochemistry and found that 31% of these tumors overexpressed p53 in the cell nucleus. The aim of the present study was...

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Identifiers

PMID: 7698586
DOI: 10.1016/0016-5085(95)90217-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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