Article
p53 protein accumulation in European hepatocellular carcinoma is not always dependent on p53 gene mutation.
Gastroenterology - 1 Apr 1995
Bourdon J C, D'Errico A, Paterlini P, Grigioni W, May E, Debuire B
Abstract excerpt
BACKGROUND/AIMS: Immunohistochemical reactivity for p53 protein is common in various human malignancies and often related to p53 gene mutation. However, in some tumor types, accumulation of wild-type p53 has been shown. Previously, we analyzed 96 European hepatocellular carcinomas using immunohis...
Topics
- Adult
- Aged
- Base Sequence
- Carcinoma, Hepatocellular
- DNA Mutational Analysis
- Europe
- Female
- Gene Expression
- Genes, p53
- Humans
- Immunohistochemistry
- Liver Neoplasms
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Tumor Suppressor Protein p53