A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region.

doi:10.1016/j.jhep.2012.12.024

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Article

A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region.

Journal of hepatology - 1 May 2013

Urabe Yuji, Ochi Hidenori, Kato Naoya, Kumar Vinod, Takahashi Atsushi, Muroyama Ryosuke, Hosono Naoya, Otsuka Motoyuki, Tateishi Ryosuke, Lo Paulisally Hau Yi, Tanikawa Chizu, Omata Masao, Koike Kazuhiko, Miki Daiki, Abe Hiromi, Kamatani Naoyuki, Toyota Joji, Kumada Hiromitsu, Kubo Michiaki, Chayama Kazuaki, Nakamura Yusuke, Matsuda Koichi

Abstract excerpt

BACKGROUND & AIMS: We performed a genome-wide association study (GWAS) of hepatitis C virus (HCV)-induced liver cirrhosis (LC) to identify predictive biomarkers for the risk of LC in patients with chronic hepatitis C (CHC). METHODS: A total of 682 HCV-induced LC cases and 1045 CHC patients of Japanese origin were genotyped by Illumina Human Hap 610-Quad bead Chip. RESULTS: Eight SNPs which showed possible...

Topics

Adult
Aged
Alleles
Asian People
Case-Control Studies
Female
Genetic Loci
Genetic Predisposition to Disease
Genetic Testing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome-Wide Association Study

Genotype

HLA-DQ alpha-Chains

HLA-DRB1 Chains

Hepacivirus

Hepatitis C

Humans

Japan

Liver Cirrhosis

Source

Open in PubMed

Identifiers

PMID: 23321320
DOI: 10.1016/j.jhep.2012.12.024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-23321320-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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