Genome-wide association study identified new susceptible genetic variants in HLA class I region for hepatitis B virus-related hepatocellular carcinoma.

doi:10.1038/s41598-018-26217-7

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Genome-wide association study identified new susceptible genetic variants in HLA class I region for hepatitis B virus-related hepatocellular carcinoma.

Scientific reports - 21 May 2018

Sawai Hiromi, Nishida Nao, Khor Seik-Soon, Honda Masao, Sugiyama Masaya, Baba Natsumi, Yamada Kayoko, Sawada Norie, Tsugane Shoichiro, Koike Kazuhiko, Kondo Yuji, Yatsuhashi Hiroshi, Nagaoka Shinya, Taketomi Akinobu, Fukai Moto, Kurosaki Masayuki, Izumi Namiki, Kang Jong-Hon, Murata Kazumoto, Hino Keisuke, Nishina Sohji, Matsumoto Akihiro, Tanaka Eiji, Sakamoto Naoya, Ogawa Koji, Yamamoto Kazuhide, Tamori Akihiro, Yokosuka Osamu, Kanda Tatsuo, Sakaida Isao, Itoh Yoshito, Eguchi Yuichiro, Oeda Satoshi, Mochida Satoshi, Yuen Man-Fung, Seto Wai-Kay, Poovorawan Yong, Posuwan Nawarat, Mizokami Masashi, Tokunaga Katsushi

Abstract excerpt

We have performed a genome-wide association study (GWAS) including 473 Japanese HBV (hepatitis B virus)-positive HCC (hepatocellular carcinoma) patients and 516 HBV carriers including chronic hepatitis and asymptomatic carrier individuals to identify new host genetic factors associated with HBV-derived HCC in Japanese and other East Asian populations. We identified 65 SNPs with P values < 10-4 located within the...

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Identifiers

PMID: 29784950
DOI: 10.1038/s41598-018-26217-7
PMCID: PMC5962604

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