Article
Genetic Variants in KIR/HLA-C Genes Are Associated With the Susceptibility to HCV Infection in a High-Risk Chinese Population.
Frontiers in immunology - 1 Jan 2021
Shen Chao, Ge Zhijun, Dong Chen, Wang Chunhui, Shao Jianguo, Cai Weihua, Huang Peng, Fan Haozhi, Li Jun, Zhang Yun, Yue Ming
Abstract excerpt
Background: KIR/HLA-C signaling pathway influences the innate immune response which is the first defense to hepatitis C virus (HCV) infection. The aim of this study was to determine the association between the genetic polymorphisms of KIR/HLA-C genes and the outcomes of HCV infection in a high-risk Chinese population. Methods: In this case-control study, four single nucleotide polymorphisms (SNPs) of KIR/HLA-C...
Topics
- Adult
- Alleles
- Case-Control Studies
- China
- Female
- Genetic Association Studies
- Genetic Predisposition to Disease
- Genotype
- HLA-C Antigens
- Hepacivirus
- Hepatitis C
- Humans
- Male
- Middle Aged