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Human leukocyte antigen variants and risk of hepatocellular carcinoma modified by hepatitis C virus genotypes: A genome-wide association study.

Hepatology (Baltimore, Md.) - 1 Feb 2018

Lee Mei-Hsuan, Huang Yu-Han, Chen Hsuan-Yu, Khor Seik-Soon, Chang Ya-Hsuan, Lin Yu-Ju, Jen Chin-Lan, Lu Sheng-Nan, Yang Hwai-I, Nishida Nao, Sugiyama Masaya, Mizokami Masashi, Yuan Yong, L'Italien Gibert, Tokunaga Katsushi, Chen Chien-Jen

Abstract excerpt

We conducted a genome-wide association study to discover genetic variants associated with hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC). We genotyped 502 HCC cases and 749 non-HCC controls using the Axiom-CHB genome-wide array. After identifying single-nucleotide polymorphism clusters located in the human leukocyte antigen (HLA) region which were potentially associated with HCC, HLA-DQB1...

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Identifiers

PMID: 28921602
DOI: 10.1002/hep.29531

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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