Article
Mendelian Randomization Using a Japanese GWAS Identifies an HLA-Linked Causal Effect of Chronic Hepatitis B on Cholangiocarcinoma Risk.
Asian Pacific journal of cancer prevention : APJCP - 1 Aug 2026
Elgeshy Khaled, Nagaoka Katsuya, Yamazaki Hajime, Honda Munenori, Nagaoka Maiko, Mizuta Takahiro, Toyota Toshinori, Maeda Daiki, Kurano Sotaro, Tanaka Kentaro, Narahara Satoshi, Inada Hiroki, Tokunaga Takayuki, Iio Etsuko, Watanabe Takehisa, Setoyama Hiroko, Uojima Haruki, Tanaka Yasuhito
Abstract excerpt
BACKGROUND: Cholangiocarcinoma (CCA) is a highly malignant cancer that develops in the bile ducts. Its incidence is particularly high in East Asian populations, but the underlying genetic factors remain unclear. To investigate potential risk factors for CCA, we conducted a Mendelian randomization study to infer causality. METHODS: Using large-scale genome-wide association study data from the BioBank Japan...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.