Article
HLA-DQB1*03 confers susceptibility to chronic hepatitis C in Japanese: a genome-wide association study.
PloS one - 1 Jan 2013
Miki Daiki, Ochi Hidenori, Takahashi Atsushi, Hayes C Nelson, Urabe Yuji, Abe Hiromi, Kawaoka Tomokazu, Tsuge Masataka, Hiraga Nobuhiko, Imamura Michio, Kawakami Yoshiiku, Aikata Hiroshi, Takahashi Shoichi, Akuta Norio, Suzuki Fumitaka, Ikeda Kenji, Kumada Hiromitsu, Karino Yoshiyasu, Toyota Joji, Tsunoda Tatsuhiko, Kubo Michiaki, Kamatani Naoyuki, Nakamura Yusuke, Chayama Kazuaki
Abstract excerpt
Hepatitis C virus (HCV) establishes a chronic infection in 70-80% of infected individuals. Many researchers have examined the effect of human leukocyte antigen (HLA) on viral persistence because of its critical role in the immune response against exposure to HCV, but almost all studies have proven to be inconclusive. To identify genetic risk factors for chronic HCV infection, we analyzed 458,207 single nucleotide...
Topics
- Asian People
- Gene Frequency
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- HLA-DQ beta-Chains
- Hepatitis C, Chronic
- Humans
- Linkage Disequilibrium