Article
Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma.
Nature genetics - 1 May 2011
Kumar Vinod, Kato Naoya, Urabe Yuji, Takahashi Atsushi, Muroyama Ryosuke, Hosono Naoya, Otsuka Motoyuki, Tateishi Ryosuke, Omata Masao, Nakagawa Hidewaki, Koike Kazuhiko, Kamatani Naoyuki, Kubo Michiaki, Nakamura Yusuke, Matsuda Koichi
Abstract excerpt
To identify the genetic susceptibility factor(s) for hepatitis C virus-induced hepatocellular carcinoma (HCV-induced HCC), we conducted a genome-wide association study using 432,703 autosomal SNPs in 721 individuals with HCV-induced HCC (cases) and 2,890 HCV-negative controls of Japanese origin. Eight SNPs that showed possible association (P < 1 × 10(-5)) in the genome-wide association study were further...
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