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Article

Activation of the Cellular Unfolded Protein Response by Recombinant Adeno-Associated Virus Vectors

8 Jan 2013

Abstract excerpt

The unfolded protein response (UPR) is a stress-induced cyto-protective mechanism elicited towards an influx of large amount of proteins in the endoplasmic reticulum (ER). In the present study, we evaluated if AAV manipulates the UPR pathways during its infection. We first examined the role of the three major UPR axes, namely, endoribonuclease inositol-requiring enzyme-1 (IRE1α), activating transcription factor 6...

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PMID: 23320106
DOI: 10.1371/journal.pone.0053845

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