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Role of the Host Cell's Unfolded Protein Response in Arenavirus Infection

25 Nov 2010

Abstract excerpt

Arenaviruses are enveloped RNA viruses with a nonlytic life cycle that cause acute and persistent infections. Here, we investigated the role of the host cell's unfolded protein response (UPR) in infection of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV). In mammalian cells, the endoplasmic reticulum (ER) chaperone protein GRP78/BiP functions as the principal sensor for the induction of the...

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PMID: 21106748
DOI: 10.1128/jvi.01782-10

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