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Article

Proteomic Landscape of Adeno-Associated Virus (AAV)-Producing HEK293 Cells

25 Oct 2021

Abstract excerpt

Adeno-associated viral (AAV) vectors are widely used for gene therapy, providing treatment for diseases caused by absent or defective genes. Despite the success of gene therapy, AAV manufacturing is still challenging, with production yields being limited. With increased patient demand, improvements in host cell productivity through various engineering strategies will be necessary. Here, we study the host cell...

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PMID: 34768929
DOI: 10.3390/ijms222111499

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