Article

Adeno-associated Virus (AAV) Synthetic Inverted Terminal Repeat Enhances Tissue Specific Transduction and Altered Vector Induced Stress Response

2026-07-13

Abstract excerpt

While adeno-associated virus (AAV) vectors have shown therapeutic benefit in clinical applications, noted challenges include low transduction efficiencies, poor cellular targeting, and vector related adverse events. Recently, it was demonstrated that a rationally designed synthetic inverted terminal repeat (SynITR) altered the AAV vector-induced DNA damage response and abrogated apoptosis in human embryonic stem c...

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Literature Corpus work: a5afb22f-0bfe-5741-b8a7-bef23ed32c01
DOI: 10.64898/2026.07.10.737493

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