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Enhanced ER protein processing gene expression increases rAAV yield and full capsid ratio in HEK293 cells

4 Sept 2024

Abstract excerpt

The recombinant adeno-associated virus (rAAV) vector is among the most promising viral vectors in gene therapy. However, the limited manufacturing capacity in human embryonic kidney (HEK) cells is a barrier to rAAV commercialization. We investigated the impact of endoplasmic reticulum (ER) protein processing and apoptotic genes on transient rAAV production in HEK293 cells. We selected four candidate genes based...

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PMID: 39230729
DOI: 10.1007/s00253-024-13281-5

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