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Manipulation of the unfolded protein response: a pharmacological strategy against coronavirus infection

2018-03-31

Abstract excerpt

Coronavirus infection induces the unfolded protein response (UPR), a cellular signalling pathway composed of three branches, triggered by unfolded proteins in the endoplasmic reticulum (ER) due to high ER load. We have used RNA sequencing and ribosome profiling to investigate holistically the transcriptional and translational response to cellular infection by murine hepatitis virus (MHV), often used as a model for...

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Literature Corpus work
17e71430-736b-5fff-b36a-bab621fc6cf2
DOI
10.1101/292979
Open publication

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Manipulation of the unfolded protein response: a pharmacological strategy against coronavirus infectionDOI 10.1101/292979
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