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Article

Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies.

Cell metabolism - 8 Jan 2013

Stenesen Drew, Suh Jae Myoung, Seo Jin, Yu Kweon, Lee Kyu-Sun, Kim Jong-Seok, Min Kyung-Jin, Graff Jonathan M

Abstract excerpt

A common thread among conserved life span regulators lies within intertwined roles in metabolism and energy homeostasis. We show that heterozygous mutations of AMP biosynthetic enzymes extend Drosophila life span. The life span benefit of these mutations depends upon increased AMP:ATP and ADP:ATP...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23312286
DOI: 10.1016/j.cmet.2012.12.006
PMCID: PMC3614013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23312286-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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