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Article

Conditional disruption of AMP kinase in dopaminergic neurons promotes Parkinson's disease-associated phenotypes in vivo.

Neurobiology of disease - 1 Dec 2021

Hang Liting, Wang Ziyin, Foo Aaron S C, Goh Geraldine W Y, Choong Huey Ching, Thundyil John, Xu Shengli, Lam Kong-Peng, Lim Kah-Leong

Abstract excerpt

Emerging studies implicate energy dysregulation as an underlying trigger for Parkinson's disease (PD), suggesting that a better understanding of the molecular pathways governing energy homeostasis could help elucidate therapeutic targets for the disease. A critical cellular energy regulator is AMP kinase (AMPK), which we have previously shown to be protective in PD models. However, precisely how AMPK function...

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PMID: 34767944
DOI: 10.1016/j.nbd.2021.105560

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