Article
Stimulating S-adenosyl-l-methionine synthesis extends lifespan via activation of AMPK.
Proceedings of the National Academy of Sciences of the United States of America - 18 Oct 2016
Ogawa Takafumi, Tsubakiyama Ryohei, Kanai Muneyoshi, Koyama Tetsuya, Fujii Tsutomu, Iefuji Haruyuki, Soga Tomoyoshi, Kume Kazunori, Miyakawa Tokichi, Hirata Dai, Mizunuma Masaki
Abstract excerpt
Dietary restriction (DR), such as calorie restriction (CR) or methionine (Met) restriction, extends the lifespan of diverse model organisms. Although studies have identified several metabolites that contribute to the beneficial effects of DR, the molecular mechanism underlying the key metabolites responsible for DR regimens is not fully understood. Here we show that stimulating S-adenosyl-l-methionine (AdoMet)...
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