Article
Wobble pairs of the HDV ribozyme play specific roles in stabilization of active site dynamics.
Physical chemistry chemical physics : PCCP - 28 Feb 2015
Sripathi Kamali N, Banáš Pavel, Réblová Kamila, Šponer Jiří, Otyepka Michal, Walter Nils G
Abstract excerpt
The hepatitis delta virus (HDV) is the only known human pathogen whose genome contains a catalytic RNA motif (ribozyme). The overall architecture of the HDV ribozyme is that of a double-nested pseudoknot, with two GU pairs flanking the active site. Although extensive studies have shown that mutation of either wobble results in decreased catalytic activity, little work has focused on linking these mutations to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.