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Article

Chronological requirements of TDP-43 function in synaptic organization and locomotive control

31 Jul 2014

Abstract excerpt

Alterations in TDP-43 are commonly found in patients suffering from amyotrophic lateral sclerosis (ALS) and the genetic suppression of the conserved homologue in Drosophila (TBPH) provokes alterations in the functional organization of motoneuron synaptic terminals, resulting in locomotive defects and reduced life span. To gain more insight into this pathological process, it is of fundamental importance to...

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PMID: 25088713
DOI: 10.1016/j.nbd.2014.07.007

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