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Article

Expansion of activated memory CD4+ T cells affects infectivity of CCR5-tropic HIV-1 in humanized NOD/SCID/JAK3null mice.

PloS one - 1 Jan 2013

Terahara Kazutaka, Ishige Masayuki, Ikeno Shota, Mitsuki Yu-ya, Okada Seiji, Kobayashi Kazuo, Tsunetsugu-Yokota Yasuko

Abstract excerpt

Humanized mice reconstituted with human hematopoietic cells have been developed as an experimental animal model for human immunodeficiency virus type 1 (HIV-1) infection. Myeloablative irradiation is usually performed to augment the engraftment of donor hematopoietic stem cells (HSCs) in recipient mice; however, some mouse strains are susceptible to irradiation, making longitudinal analysis difficult. We...

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Source

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Identifiers

PMID: 23301078
DOI: 10.1371/journal.pone.0053495
PMCID: PMC3534664

Genes

CCR5
JAK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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