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Article

Effective elicitation of human effector CD8+ T Cells in HLA-B*51:01 transgenic humanized mice after infection with HIV-1.

PloS one - 1 Jan 2012

Sato Yoshinori, Nagata Sayaka, Takiguchi Masafumi

Abstract excerpt

Humanized mice are expected to be useful as small animal models for in vivo studies on the pathogenesis of infectious diseases. However, it is well known that human CD8(+) T cells cannot differentiate into effector cells in immunodeficient mice transplanted with only human CD34(+) hematopoietic stem cells (HSCs), because human T cells are not educated by HLA in the mouse thymus. We here established HLA-B*51:01...

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Share to CD8-Positive T-Lymphocytes
Share to CX3C Chemokine Receptor 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Janus Kinase 3

Share to Mice, Inbred NOD

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Source

Open in PubMed Open full text

Identifiers

PMID: 22880104
DOI: 10.1371/journal.pone.0042776
PMCID: PMC3412802

Genes

CCR7
CXCR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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