Article
Long-term engraftment of human natural T regulatory cells in NOD/SCID IL2rγc(null) mice by expression of human IL-2.
PloS one - 1 Jan 2012
Abraham Sojan, Pahwa Rajendra, Ye Chunting, Choi Jang-Gi, Pahwa Savita, Jaggaiahgari Shashidhar, Raut Ashwin, Chen Shuiping, Manjunath N, Shankar Premlata
Abstract excerpt
Regulatory T cells are essential to maintain immune homeostasis and prevent autoimmunity. Therapy with in vitro expanded human nT(Regs) is being tested to prevent graft versus host disease, which is a major cause for morbidity and mortality associated with hematopoietic stem cell transplantation. Their usefulness in therapy will depend on their capacity to survive, migrate appropriately and retain suppressive...
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