Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Establishment of a Novel Humanized Mouse Model To Investigate In Vivo Activation and Depletion of Patient-Derived HIV Latent Reservoirs

9 Jan 2019

Abstract excerpt

Sustained remission of HIV infection is prevented by a persistent reservoir of latently infected cells capable of reinitiating systemic infection and viremia. To evaluate strategies to reactivate and deplete this reservoir, we developed and characterized a new humanized mouse model consisting of highly immunodeficient mice intrasplenically injected with peripheral blood mononuclear cells from long-term...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV Research and Treatment
Share to Immune Cell Function and Interaction
Share to Mosquito-borne diseases and control

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30626677
DOI: 10.1128/jvi.02051-18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Establishment of a Novel Humanized Mouse Model To Investigate In Vivo Activation and Depletion of Patient-Derived HIV Latent ReservoirsPMID 30626677Read ↗

A mature macrophage is a principal HIV-1 cellular reservoir in humanized mice after treatment with long acting antiretroviral therapySemantic proximity Read ↗

Critical Role for CD4+T Cells in Controlling Retrovirus Replication and Spread in Persistently Infected MiceSemantic proximity Read ↗

Humanized Bone Marrow-Liver-Thymus Mice for Studying HIV-1 Persistence in Liver and Lung CD4+ T and Myeloid Cell Subsets during Antiretroviral TherapySemantic proximity Read ↗

Suppression of Human Immunodeficiency Virus Type 1 (HIV-1) Viremia with Reverse Transcriptase and Integrase Inhibitors, CD4 <sup>+</sup> T-Cell Recovery, and Viral Rebound upon Interruption of Therapy in a New Model for HIV Treatment in the Humanized Rag2 <sup>−/−</sup> γ <sub>c</sub> <sup>−/−</sup> MouseSemantic proximity Read ↗

Recent Updates on Mouse Models for Human Immunodeficiency, Influenza, and Dengue Viral InfectionsSemantic proximity Read ↗

Humanized Mouse Systems to Study Viral Infection: A New Era in Immunology ResearchSemantic proximity Read ↗

Inhibition of caspase pathways limits CD4+ T cell loss and restores host anti-retroviral function in HIV-1 infected humanized mice with augmented lymphoid tissueSemantic proximity Read ↗

A Hitchhiker's guide to humanized mice: new pathways to studying viral infections.Semantic proximity Read ↗

Nef dimerization defect abrogates HIV viremia and associated immune dysregulation in the Bone Marrow-Liver-Thymus-Spleen (BLTS) humanized mouse modelSemantic proximity Read ↗

Modeling AIDS in a mouse.Semantic proximity Read ↗

Impact of Suboptimal APOBEC3G Neutralization on the Emergence of HIV Drug Resistance in Humanized Mice.Semantic proximity Read ↗

Impact of suboptimal APOBEC3G neutralization on the emergence of HIV drug resistance in humanized miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.