Article

CXCR4-associated depletion of bone marrow CD34 <sup>+</sup> cells following CCR5-tropic HIV-1 infection of humanized NOD/SCID/JAK3 <sup>null</sup> mice and partial protection of those cells by a promotor-targeting shRNA

2017-09-19

Abstract excerpt

<h4>Objectives</h4> Hematological abnormalities that include changes in bone marrow, such as in anemia and pancytopenia, are common among human immunodeficiency virus (HIV)-infected patients, particularly in the advanced stage of disease. This study aimed to provide better experimental evidence of such manifestations in animal models. <h4>Design</h4> NOD/SCID/JAK3 null (NOJ) mice were transplanted with human co...

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Literature Corpus work: 84d15cb1-7bd7-56ef-a336-b9cfe930f69a
DOI: 10.1101/190702

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CXCR4-associated depletion of bone marrow CD34 <sup>+</sup> cells following CCR5-tropic HIV-1 infection of humanized NOD/SCID/JAK3 <sup>null</sup> mice and partial protection of those cells by a promotor-targeting shRNADOI 10.1101/190702Read

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