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Development of a low-dose PBMC humanized mouse model using CD47;Rag2;IL2rγ triple KO mice: Enhanced leukocyte reconstitution and extended experimental window

2026-03-30

Abstract excerpt

Humanized mice (hu-mice), which recapitulate the human immune system, have become increasingly important for preclinical immunotherapy studies. Among these models, the human peripheral blood mononuclear cells (PBMC)-engrafted hu-mice model is the simplest and fastest. However, its utility is hindered by the development of lethal graft-versus-host disease (GvHD) and the insufficient reconstitution of human leukocyt...

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Literature Corpus work: cd45ee5b-dc19-5142-8f31-ca4a8d84a4eb
DOI: 10.64898/2026.03.25.714298

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