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Article

Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment of Hematopoietic Stem Cells.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2016

Hasgur Suheyla, Aryee Ken Edwin, Shultz Leonard D, Greiner Dale L, Brehm Michael A

Abstract excerpt

Immunodeficient mice are being used as recipients of human hematopoietic stem cells (HSC) for in vivo analyses of human immune system development and function. The development of several stocks of immunodeficient Prkdc (scid) (scid), or recombination activating 1 or 2 gene (Rag1 or Rag2) knockout mice bearing a targeted mutation in the gene encoding the IL2 receptor gamma chain (IL2rγ), has greatly facilitated...

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Identifiers

PMID: 27150084
DOI: 10.1007/978-1-4939-3661-8_4
PMCID: PMC5268072

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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